Expression pattern of the FGF-related proto-oncogene int-2 suggests multiple roles in fetal development.
نویسندگان
چکیده
The FGF-related proto-oncogene int-2 is implicated in mouse embryogenesis, since it is expressed in specific tissues during gastrulation and neurulation (Wilkinson et. al. 1988). Here, we describe the expression of this gene during subsequent fetal development, int-2 transcripts are restricted to Purkinje cells in the cerebellum and to regions of the developing retina containing early-stage differentiating cells. This high level expression is not detected in the mature cerebellum or retina. In addition, int-2 RNA is detected in the mesenchyme of the developing teeth and in sensory regions of the inner ear. This complex and dynamic pattern suggests multiple roles of this proto-oncogene during fetal development of the mouse.
منابع مشابه
Developmental expression of the Xenopus int-2 (FGF-3) gene: activation by mesodermal and neural induction.
We have used a probe specific for the Xenopus homologue of the mammalian proto-oncogene int-2 (FGF-3) to examine the temporal and spatial expression pattern of the gene during Xenopus development. int-2 is expressed from just before the onset of gastrulation through to prelarval stages. In the early gastrula, it is expressed around the blastopore lip. This is maintained in the posterior third o...
متن کاملMice homozygous for a targeted disruption of the proto-oncogene int-2 have developmental defects in the tail and inner ear.
We derived mice that carry a targeted insertion of a neor gene in the int-2 (Fgf-3) proto-oncogene coding sequences. The mutation was found to be recessive and mice that were homozygous for the insertion did not often survive to adulthood. The mutant mice had defects in the development of the tail and inner ear that could be correlated with disruption of int-2 expression in the posterior primit...
متن کاملTHE MUTATIONS OF RET PROTO-ONCOGENE IN MEDULLARY THYROID CARCINOMAS IN IRAN
MeduIIary thyroid carcinoma (MTC) occurs both sporadically and in the autosomal dominantly inherited multiple endocrine neoplasia (MEN) type 2 syndromes. The distinction between true sporadic MTC and a new mutation familial case is important for future clinical management of both the patient and family. The susceptibility gene for hereditary MTC is the RET proto-oncogene. DNA analysis for g...
متن کاملNotch4/int-3, a mammary proto-oncogene, is an endothelial cell-specific mammalian Notch gene.
The int-3 oncogene was identified as a frequent target in Mouse Mammary Tumor Virus (MMTV)-induced mammary carcinomas and encodes the intracellular domain of a novel mouse Notch gene. To investigate the role of the int-3 proto-oncogene in mouse development and carcinogenesis, we isolated cDNA clones corresponding to the entire coding potential of the int-3 proto-oncogene. We propose to name thi...
متن کاملINTRODUCTION The fibroblast growth factor (FGF) family is composed of a number of heparin-binding proteins characterized by their potent mitogenic effects on cells, their ability to promote migration and differentiation, and to induce angiogenesis
The fibroblast growth factor (FGF) family is composed of a number of heparin-binding proteins characterized by their potent mitogenic effects on cells, their ability to promote migration and differentiation, and to induce angiogenesis (reviewed by Folkman and Klagsbrun, 1987; Gospodarowicz, 1988). FGF has also been implicated in the regulation of vertebrate development. Mesoderm-inducing activi...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
- Development
دوره 105 1 شماره
صفحات -
تاریخ انتشار 1989